International Journal of Computer and Communication Technology


In the present work, we discuss an anaysis about the localization of different members of scramblase protein family. Different scramblase sequences were picked up from organisms of all eukaryotic phyla and their localization were predicted using the P-SORT programme. Our analysis showed that the scramblase protein family shows multiple subcellular localization. Most proteins were found to be localized to the cytoplasm, where as others were found to be present in the nucleus or mitochondria. Interestingly, we found that in yeast, all putative scramblases were localized in the nucleus with a reliability of more than 95%. Our analysis shows that scramblases are a family of protein having diversed cellular localization and hence hypothesized to be performing multiple cellular functions in various organisms





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